Effects of alpha-trinositol on systemic inflammation and renal function in ovine bacterial sepsis.

@article{Lingnau1997EffectsOA,
  title={Effects of alpha-trinositol on systemic inflammation and renal function in ovine bacterial sepsis.},
  author={Werner Lingnau and Roy W McGuire and Michael Booke and Lillian D. Traber and Daniel Lee Traber},
  journal={Shock},
  year={1997},
  volume={8 3},
  pages={179-85}
}
Neuronally secreted peptides are important mediators of hemodynamic changes in the systemic inflammatory response. The inositol derivative D-myo-inositol[1,2,6]triphosphate (alpha-trinositol) has been demonstrated to be a specific nonpeptide antagonist of vasoconstriction induced by neuropeptide Y. We induced sepsis by a 48 h continuous infusion of… CONTINUE READING