Effects of alpha-methyl tyrosine and adrenergic blocking agents on the facilitating action of amphetamine and nicotine on learning in rats

@article{Orsingher1971EffectsOA,
  title={Effects of alpha-methyl tyrosine and adrenergic blocking agents on the facilitating action of amphetamine and nicotine on learning in rats},
  author={Otto A. Orsingher and Susana Fulginiti},
  journal={Psychopharmacologia},
  year={1971},
  volume={19},
  pages={231-240}
}
dl-amphetamine sulphate (2 mg/kg) and nicotine (0.2 mg/kg) showed a facilitatory action on the acquisition of a conditioned response in a shuttle-box by rats and this was reversed by pretreatment with α-MT (30 mg/kg). Pretreatment with dibenamine (10 mg/kg) impaired the action either of amphetamine or nicotine. Nethalide (5–10 mg/kg) exerted a partial protection on the depressant effect produced by the interaction between dibenamine and nicotine. Animals treated with α-MT (30 mg/kg) and kept in… CONTINUE READING