Effects of alpha-lipoic acid on endothelial function in aged diabetic and high-fat fed rats.

@article{Sena2008EffectsOA,
  title={Effects of alpha-lipoic acid on endothelial function in aged diabetic and high-fat fed rats.},
  author={Cristina Maria Sena and Edelvan Nunes and Thiago Quinellato Louro and Teresa Proença and R Fernandes and Michael R. Boarder and Raquel Seiça},
  journal={British journal of pharmacology},
  year={2008},
  volume={153 5},
  pages={894-906}
}
BACKGROUND AND PURPOSE This study was conducted to investigate the effects of alpha-lipoic acid (alpha-LA) on endothelial function in diabetic and high-fat fed animal models and elucidate the potential mechanism underlying the benefits of alpha-LA. EXPERIMENTAL APPROACH Plasma metabolites reflecting glucose and lipid metabolism, endothelial function, urinary albumin excretion (UAE), plasma and aortic malondialdehyde (MDA) and urinary 8-hydroxydeoxyguanosine (8-OHdG) were assessed in non… CONTINUE READING

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