Effects of alloxan diabetes on the turnover of rat liver glycogen synthase. Comparison with liver phosphorylase.

@article{Bahnak1982EffectsOA,
  title={Effects of alloxan diabetes on the turnover of rat liver glycogen synthase. Comparison with liver phosphorylase.},
  author={Bruce R. Bahnak and Alvin H. Gold},
  journal={The Journal of biological chemistry},
  year={1982},
  volume={257 15},
  pages={
          8775-80
        }
}
Rat liver glycogen synthase shows almost a 2-fold increase in activity 8 days after onset of alloxan diabetes. Immunological and catalytic criteria indicate that the change in activity is associated with an increase in the amount of enzyme in the diabetic. Apparent rates of degradation were determined for isolated glycogen synthase and phosphorylase from the livers of 2-, 5-, and 8-day diabetic, insulin-treated diabetic and normal rats using the double isotope ([3H]leucine and [14C]leucine… CONTINUE READING

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