• Corpus ID: 42624659

Effects of allitridi on intracellular Ca2+ concentration in isolated rat brain cells.

@article{Ma1999EffectsOA,
  title={Effects of allitridi on intracellular Ca2+ concentration in isolated rat brain cells.},
  author={X H Ma and X X Pan and T P Liu},
  journal={Zhongguo yao li xue bao = Acta pharmacologica Sinica},
  year={1999},
  volume={20 7},
  pages={
          609-12
        }
}
  • X. Ma, X. Pan, T. P. Liu
  • Published 1 July 1999
  • Biology, Chemistry, Medicine
  • Zhongguo yao li xue bao = Acta pharmacologica Sinica
AIM To study actions of allitridi extracted from garlic on intracellular calcium in isolated rat brain cells. METHODS Brain cells were isolated from newborn rat brain with Fura 2-AM measurements of intracellular Ca2+ concentration ([Ca2+]i). RESULTS Allitridi 1-100 mumol.L-1 concentration-dependently blocked increases of [Ca2+]i caused by potassium chloride and sodium glutamate (Glu) with IC50 of 59.7 and 69.9 mumol.L-1 respectively. Allitridi 100 mumol.L-1 blocked norepinephrine (Nor…