Effects of all-trans retinoic acid on orphan receptor APJ signaling in spontaneously hypertensive rats.

@article{Zhong2005EffectsOA,
  title={Effects of all-trans retinoic acid on orphan receptor APJ signaling in spontaneously hypertensive rats.},
  author={J Zhong and Dong-yang Huang and Ge-fei Liu and Hai-yan Jin and Y Yang and Yifan David Li and X Song and Kun Du},
  journal={Cardiovascular research},
  year={2005},
  volume={65 3},
  pages={743-50}
}
OBJECTIVE Studies show general agreement that all-trans retinoic acid (atRA) has been linked to the regulation of G protein-coupled receptor (GPCRs) signaling. To further validate effects of atRA on the cardiovascular GPCRs, the present study was designed to assess whether atRA will modulate orphan receptor APJ, a homologue of angiotensin II type 1 (AT(1)) receptor. METHODS Real-time polymerase chain reaction and Western blot methods were performed to examine the expression of APJ and its… CONTINUE READING

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