Effects of alginase on the natural history and antibiotic therapy of experimental endocarditis caused by mucoid Pseudomonas aeruginosa.

@article{Bayer1992EffectsOA,
  title={Effects of alginase on the natural history and antibiotic therapy of experimental endocarditis caused by mucoid Pseudomonas aeruginosa.},
  author={Arnold S. Bayer and S Park and Marcelo C. Ramos and Cynthia C. Nast and F Eftekhar and Neal L. Schiller},
  journal={Infection and immunity},
  year={1992},
  volume={60 10},
  pages={3979-85}
}
The exopolysaccharide (alginate) of mucoid strains of Pseudomonas aeruginosa is believed to be an important virulence factor. The ability of an alginate-deploymerizing enzyme (alginase) to modify the polymorphonuclear leukocyte (PMN)-directed and antibiotic-mediated phagocytosis and killing of mucoid P. aeruginosa was studied both in vitro and in vivo. In vitro, pretreatment of a mucoid P. aeruginosa strain (144MR) resulted in a significant enhancement of PMN phagocytosis and killing of the… CONTINUE READING