Effects of aldosterone and potassium-sparing diuretics on electrical potential differences across the distal nephron.

@article{Gross1977EffectsOA,
  title={Effects of aldosterone and potassium-sparing diuretics on electrical potential differences across the distal nephron.},
  author={John B. Gross and Juha P. Kokko},
  journal={The Journal of clinical investigation},
  year={1977},
  volume={59 1},
  pages={82-9}
}
We have previously shown that the transtubular potential of the rabbit cortical collecting tubule varies in concert with changes in plasma mineralocorticoid levels, while the potential of the distal convoluted tubule is invariant with such changes. In the present studies we have examined the effects of in vitro addition of d-aldosterone to isolated tubules, as well as the effects of triamterene and spirolactone. d-Aldosterone (0.2 mum added to the perfusate or 1 muM added to the bathing medium… CONTINUE READING