Effects of alcohol on folate metabolism: implications for carcinogenesis.

  title={Effects of alcohol on folate metabolism: implications for carcinogenesis.},
  author={Joel B. Mason and Sang-Woon Choi},
  volume={35 3},
Epidemiologic observations implicate excess ethanol ingestion as well as low dietary folate intake as risk factors for several cancers. Moreover, the epidemiologic observations support the concept of a synergistic effect between these two factors. Such a relation is biologically plausible because ethanol impedes the bioavailability of dietary folate and is known to inhibit select folate-dependent biochemical reactions. For example, alcohol ingestion in animals is known to inhibit folate… CONTINUE READING


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