Effects of alcohol (BAC 0.5‰) and ecstasy (MDMA 100 mg) on simulated driving performance and traffic safety

@article{Veldstra2011EffectsOA,
  title={Effects of alcohol (BAC 0.5‰) and ecstasy (MDMA 100 mg) on simulated driving performance and traffic safety},
  author={Janet L Veldstra and Karel A. Brookhuis and D. de Waard and Barbara H. W. Molmans and Alain G. Verstraete and Gisela Skopp and Ricarda Jantos},
  journal={Psychopharmacology},
  year={2011},
  volume={222},
  pages={377 - 390}
}
RationalAn increasing number of fatal road-accidents have been reported in which ecstasy was found in the blood of drivers. Although, ecstasy is frequently found to have been used in combination with alcohol, studies on the acute effects of ecstasy co-administered with alcohol on driving performance are relatively rare.ObjectiveThe present study was designed to establish the extent of driver impairment as a consequence of ecstasy or combined ecstasy and alcohol use as compared to driving under… 
The influence of alcohol (0.5‰) on the control and manoeuvring level of driving behaviour, finding measures to assess driving impairment: A simulator study
Abstract Objective The influence of psychoactive substances on driving performance and traffic safety has been extensively studied. Research on the influence of alcohol at the control level of
Effects of alcohol on automated and controlled driving performances
TLDR
Automated driving parameters such as standard deviation of lateral position measured with the road tracking and car following scenarios were impaired by alcohol, notably with the highest dose.
Effects of stimulant drugs on actual and simulated driving: perspectives from four experimental studies conducted as part of the DRUID research consortium
TLDR
These studies were conducted to provide scientific basis for harmonized pan-European regulations of driving under the influence (DUI) of stimulants and to gain new insights to the degree of impairment caused by psychoactive drugs and their actual impact on road safety.
Incidence of fatalities of road traffic accidents associated with alcohol consumption and the use of psychoactive drugs: A 7-year survey (2011-2017).
TLDR
The findings of this study suggest that alcohol and psychoactive substances are probably risk factors for RTA-related fatalities.
Variation of performance, of self-reported alertness and effort as a function of low doses of alcohol and of driving experience
Purpose Alcohol is the most frequent detected substance in the automobile fatal crashes but its precise mode of action on mental state is not always clear, notably when combined with lack of driving
Comparing treatment effects of oral THC on simulated and on-the-road driving performance: testing the validity of driving simulator drug research
TLDR
The driving simulator was proven to be sensitive for demonstrating dronabinol-induced effects particularly at higher doses, and inter-individual variability seemed higher in the simulator than on the road which may have potential effects on the clinical inferences made from simulator driving.
Effects of acute alcohol consumption on measures of simulated driving: A systematic review and meta-analysis.
TLDR
It is demonstrated that lateral (SDLP and LC) and longitudinal (SDSP) vehicle control measures in a driving simulator are impaired with acute alcohol consumption, however, SDLP appears to be a more sensitive indicator of driving impairment than other driving performance variables and the results of the present study support its use as a performance outcome when examining alcohol-induced simulated driving impairment.
A Review of Alcohol‐Impaired Driving: The Role of Blood Alcohol Concentration and Complexity of the Driving Task
TLDR
The scientific literature provides a high degree of confidence to support the conclusion that a BAC of 0.050% impairs faculties required in the operation of a motor vehicle.
Illicit Drugs among Crashed Drivers, A First Toxicological Investigation in Albania
This study aims to investigate the presence of drugs in this group of drivers who already had a crash (injured or killed drivers). By law, the prosecutor is the authority who requests the
Conversion factors for assessment of driving impairment after exposure to multiple benzodiazepines/z-hypnotics or opioids.
TLDR
Conversion factors to calculate diazepam and morphine equivalents for benzodiazepines/z-hypnotics and selected opioids, respectively, have been operative in the Norwegian Road Traffic Act as of February 2016.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 53 REFERENCES
Effects of MDMA (ecstasy), and multiple drugs use on (simulated) driving performance and traffic safety
TLDR
Driving under the influence of MDMA alone is certainly not safe; however, driving back (home) after a dance party where MDMA users regularly combine MDMA with a host of other drugs can be described as extremely dangerous.
MDMA and alcohol effects, combined and alone, on objective and subjective measures of actual driving performance and psychomotor function
TLDR
MDMA moderated the impairing effects of a low dose of alcohol on road tracking performance but it could not overcome alcohol-induced impairment on other aspects of driving behavior or driving related performance.
Driving under the effects of drugs of abuse: studies of oral fluid
Introduction: This study includes the evaluation of the use of drugs of abuse ratio in leisure environments, in order to determine which drugs are the most widely used, which are normally used in
Stimulant effects of 3,4-methylenedioxymethamphetamine (MDMA) 75 mg and methylphenidate 20 mg on actual driving during intoxication and withdrawal.
TLDR
Collectively, these data indicate that MDMA is a stimulant drug that may improve certain aspects of the driving task, such as road-tracking performance, but may reduce performance in other aspects ofThe driving task; such as accuracy of speed adaptation during car-following performance.
Acute neuropsychological effects of MDMA and ethanol (co-)administration in healthy volunteers
TLDR
Co-administration of MDMA and ethanol did not exacerbate the effects of either drug alone, and impaired memory function was consistently observed after all drug conditions, whereas impairment of psychomotor function and attention was less consistent across drug conditions.
Acute Effects of 3,4-Methylenedioxymethamphetamine (MDMA) on Behavioral Measures of Impulsivity: Alone and in Combination with Alcohol
TLDR
The lack of interaction indicated that the CNS stimulant effects of MDMA were never sufficient to overcome alcohol-induced impairment of impulse control or risk-taking behavior.
3,4-Methylenedioxymethamphetamine (ecstasy) and alcohol interactions in humans: psychomotor performance, subjective effects, and pharmacokinetics.
TLDR
MDMA reversed the subjective sedation induced by alcohol but did not reduce drunkenness feelings, and the MDMA-alcohol combination induced longer lasting euphoria and well being than MDMA or alcohol alone.
Acute psychomotor effects of MDMA and ethanol (co-) administration over time in healthy volunteers
TLDR
Results show that subjects were more aroused when intoxicated with both substances combined compared with placebo, but psychomotor accuracy was significantly impaired, which may have implications for general neuropsychological functioning.
Dissociable Effects of a Single Dose of Ecstasy (MDMA) on Psychomotor Skills and Attentional Performance
TLDR
MDMA improved psychomotor performance, such as movement speed and tracking performance in a single task, as well as in a divided attention task, and impaired the ability to predict object movement under divided attention.
Psychoactive substance use and the risk of motor vehicle accidents.
TLDR
It is concluded that drug use, especially alcohol, benzodiazepines and multiple drug use and drug-alcohol combinations, among vehicle drivers increases the risk for a road trauma accident requiring hospitalisation.
...
1
2
3
4
5
...