Effects of airway inflammation on cough response in the guinea pig.

@article{Xiang1998EffectsOA,
  title={Effects of airway inflammation on cough response in the guinea pig.},
  author={Anbo Xiang and Yoshiyuki Uchida and Akihiro Nomura and Hiroaki Iijima and Feng Dong and M. J. Zhang and Shu Hasegawa},
  journal={Journal of applied physiology},
  year={1998},
  volume={85 5},
  pages={1847-54}
}
We have developed a guinea pig model for cough related to allergic airway inflammation. Unanesthetized animals were exposed to capsaicin aerosols for 10 min, and cough frequency was counted during this period. The cough evaluation was performed by the following three methods: visual observation, acoustic analysis, and monitoring of pressure changes in the body chamber. These analyses clearly differentiated a cough from a sneeze. To elucidate the relationship between cough response and airway… CONTINUE READING