Effects of airway calibre on lung delivery of nebulised salbutamol.

  title={Effects of airway calibre on lung delivery of nebulised salbutamol.},
  author={Brian J Lipworth and David Walter John Clark},
  volume={52 12},
BACKGROUND A study was undertaken to test the hypothesis that airway calibre may alter lung deposition and therefore lung bioavailability of inhaled drugs as a result of narrowed airways reducing peripheral drug delivery. This was evaluated using the early lung absorption profile of salbutamol over the first 30 minutes after inhalation. METHODS Three groups were compared: (1) 10 normal subjects with mean forced expiratory volume in one second (FEV1) 109.5% predicted and mid forced expiratory… CONTINUE READING
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