Effects of aging on morphine withdrawal in the rat.

Abstract

Little is known about the effects of aging on the process of opiate dependence and withdrawal in the rat. The present study was undertaken to quantitate naloxone-precipitated opiate withdrawal in young (3-4 months old) and aged (24 month old) Long-Evan female rats. Following addiction to morphine, young and aged rats were evaluated for tail skin temperature… (More)

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