Effects of aging on male fertility?

@article{Plas2000EffectsOA,
  title={Effects of aging on male fertility?},
  author={Eugen G. Plas and Peter Berger and Martin Hermann and Heinz Pfl{\"u}ger},
  journal={Experimental Gerontology},
  year={2000},
  volume={35},
  pages={543-551}
}
Aging and the Male Gonads
TLDR
Various agerelated effects on Sertoli cells and Leydig cells are seen, with subsequent effects on the production of sperm and testosterone, and the effects of aging on testes are outlined.
Aging of the Male Germline: Influence of Advanced Male Age on ReproductiveOutcome
TLDR
Setting an age threshold for APA would be of great value to males thinking of delaying parenthood, and to physicians for medical advice purposes, and additional research to better elucidate the effects of APA on fertility and offspring’s health is needed.
Fertility and ageing.
TLDR
The late 20th century trend to delay birth of the first child until the age at which female fecundity or reproductive capacity is lower has increased the incidence of age-related infertility and stimulated interest in the possible factors in the female and the male that may contribute to the decline in fecundities with age.
The ageing male reproductive tract
TLDR
This review discusses morphological/histological changes occurring in these organs and current views and concepts of the underlying pathology, and emphasizes the molecular/cellular pathways leading to reduced testicular/penile function and proliferative disorders of the prostate gland.
Aging and male reproductive function: a mitochondrial perspective.
TLDR
Evidence is reviewed that suggests that mitochondria constitute a common link between aging and fertility loss, and that these organelles play a prominent role in this process.
Aging of the human ovary and testis
Common Male Infertility Disorders: Aging
TLDR
The effects of paternal age on a couple’s fertility are real and may be greater than has previously been thought, and Mechanisms of cell senescence have been well studied in the last decade, and the free radical theory has brought considerable attention.
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TLDR
There were no differences between older men and younger men, except for decreased sperm motility in the older group which, however, reached nearly normal values according to World Health Organization criteria.
Leydig cell numbers, daily sperm production, and serum gonadotropin levels in aging men.
TLDR
The highest FSH levels were found in men with the lowest rates of sperm production, and FSH and daily sperm production were inversely correlated even after the effects of age were removed, showing that the response of the human testis to aging is variable.
Effect of parental age on fertilization and pregnancy characteristics in couples treated by intracytoplasmic sperm injection.
TLDR
It is concluded that the influence on pregnancy outcome after ICSI is related mostly to maternal and not paternal age, while a strong negative correlation was found with maternal ageing.
Influence of age on sperm production and testicular weights in men.
TLDR
Age-related changes in daily sperm production (DSP) and testicular weights were investigated in paired testes from 89 men aged 21-50 years and 43 men aged 51-80 years and the correlations were weakened by removing the effect of age.
Ageing of the hypothalamo-pituitary-testicular axis in men.
TLDR
Both spermatogenesis and fertility as well as Leydig cell function do decline with age, as shown by a decrease of +/- 35% of total and of 50% of free testosterone levels between the age of 20 and 80 years.
[Spermatogenesis in the aged--a borderland between normal and pathologic anatomy].
TLDR
In men, older than 65 years, further degenerative changes of the germ cells and of the germinal epithelium regularly can be found, which have negative effects on the spermatogoniogensis and of meiosis.
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TLDR
This review will consider ageing and critical illness in addition to specific chronic illnesses, but will not consider diseases specific to the testis which affect gonadal function.
Reproductive functions in young fathers and grandfathers.
TLDR
It is concluded that sperm counts and fertilizing capacity of sperm are not negatively influenced by old age, at least not in men with sustained sexual activity, however, the pituitary as well as the testis show signs of decreased endocrine reserve capacity in old age.
The effect of age on the frequency of sperm chromosomal abnormalities in normal men.
TLDR
The results do not support the hypothesis of an increased risk of trisomy with paternal age, and there was a significant negative correlation between age and the frequency of hyperhaploid complements and structural abnormalities.
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