Effects of aging on mRNA profiles for drug-metabolizing enzymes and transporters in livers of male and female mice.

@article{Fu2012EffectsOA,
  title={Effects of aging on mRNA profiles for drug-metabolizing enzymes and transporters in livers of male and female mice.},
  author={Zidong Donna Fu and Iv{\'a}n L. Csanaky and Curtis D. Klaassen},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2012},
  volume={40 6},
  pages={1216-25}
}
Aging is a physiological process characterized by progressive functional decline in various organs over time. To reveal possible molecular mechanisms of altered xenobiotic disposition and toxicity in elderly individuals, age-dependent mRNA profiles for 101 xenobiotic-processing genes (XPGs), including seven uptake transporters, 41 phase I enzymes, 36 phase II enzymes, 10 efflux transporters, and seven transcription factors, were characterized in livers of male and female mice from 3 to 27… CONTINUE READING
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