Effects of aging on inositol 1,4,5-triphosphate-induced Ca(2+) release in unfertilized mouse oocytes.

@article{Takahashi2000EffectsOA,
  title={Effects of aging on inositol 1,4,5-triphosphate-induced Ca(2+) release in unfertilized mouse oocytes.},
  author={Tohru Takahashi and Hitoshi Saito and Masahiko Hiroi and Kenichiro Doi and Eiji Takahashi},
  journal={Molecular reproduction and development},
  year={2000},
  volume={55 3},
  pages={299-306}
}
We previously demonstrated in the mouse oocyte that in vivo postovulatory aging significantly suppresses activity of the endoplasmic reticulum (ER) Ca(2+)-ATPase (Igarashi et al. 1997. Mol Reprod Dev 48:383-390). We undertook the present study to further examine the effects of oocyte aging on Ca(2+) release from the inositol 1,4,5-triphosphate (InsP(3))-sensitive Ca(2+) channels of the ER membrane, because not only Ca(2+) reuptake, but also Ca(2+) release from the ER, substantially affect Ca(2… CONTINUE READING

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