Effects of aging on N-methyl-D-aspartate (NMDA)-induced GnRH and LH release in female rats.

@article{Arias1996EffectsOA,
  title={Effects of aging on N-methyl-D-aspartate (NMDA)-induced GnRH and LH release in female rats.},
  author={Patricia Arias and Silvia Carbone and Berta Szwarcfarb and Carlos Feleder and Marta Su{\'a}rez Rodr{\'i}guez and Pablo Scacchi and Jaime A. Moguilevsky},
  journal={Brain research},
  year={1996},
  volume={740 1-2},
  pages={234-8}
}
In order to evaluate if the changes of the hypothalamic-pituitary-ovary axis that induce a decrease in fertility and modifications in the sexual cycles during senescence involve modifications in the regulatory action of excitatory amino acid neurotransmission on GnRH neurons, we measured the in vitro effects of NMDA on GnRH release by the anterior preoptic and medial basal hypothalamic areas (APOA-MBH) of castrated aging (18 months old) and young (90 days of age) rats. In a second series of… CONTINUE READING