Effects of aging and gender on the spatial organization of nuclei in single human skeletal muscle cells.

@article{Cristea2010EffectsOA,
  title={Effects of aging and gender on the spatial organization of nuclei in single human skeletal muscle cells.},
  author={Alexander Cristea and Rizwan Qaisar and Patrick Karlsson Edlund and Joakim Lindblad and Ewert Bengtsson and L. -T. Larsson},
  journal={Aging cell},
  year={2010},
  volume={9 5},
  pages={685-97}
}
The skeletal muscle fibre is a syncitium where each myonucleus regulates the gene products in a finite volume of the cytoplasm, i.e., the myonuclear domain (MND). We analysed aging- and gender-related effects on myonuclei organization and the MND size in single muscle fibres from six young (21-31 years) and nine old men (72-96 years), and from six young (24-32 years) and nine old women (65-96 years), using a novel image analysis algorithm applied to confocal images. Muscle fibres were… CONTINUE READING
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