Effects of ageing on muscarinic receptor subtypes and function in rat urinary bladder

@article{Schneider2005EffectsOA,
  title={Effects of ageing on muscarinic receptor subtypes and function in rat urinary bladder},
  author={Tim Schneider and Peter Hein and Martina B. Michel-Reher and Martin C Michel},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2005},
  volume={372},
  pages={71-78}
}
We compared the density and function of M2 and M3 muscarinic acetylcholine receptor subtypes in the urinary bladder of young adult (3 months) and old (23 months) male Wistar rats. Old rats had a reduced density of muscarinic receptors (96±10 vs. 156±21 fmol/mg protein), but competition experiments with the M3-selective darifenacin did not indicate alterations in the relative roles of M2 and M3 receptors, with the former being more abundant. The amount of immunodetectable α-subunits of various G… CONTINUE READING