Effects of ageing and exogenous melatonin on pituitary responsiveness to GnRH in ewes during anestrus and the reproductive season.

@article{Forcada2007EffectsOA,
  title={Effects of ageing and exogenous melatonin on pituitary responsiveness to GnRH in ewes during anestrus and the reproductive season.},
  author={Fernando Forcada and J A Abecia and Adriana Casao and Jos{\'e} Alvaro Cebri{\'a}n-P{\'e}rez and Teresa Mui{\~n}o-Blanco and Inmaculada Palac{\'i}n},
  journal={Theriogenology},
  year={2007},
  volume={67 4},
  pages={855-62}
}
The study examined the effect of melatonin implants on in vivo pituitary responsiveness to GnRH in control, fully productive (5.7+/-0.4 years old, n=17) and aged (10.7+/-0.3 years old, n=14) ovariectomized, estradiol-treated Rasa Aragonesa ewes. On 27 February, eight ewes in each age group received a single implant containing 18 mg melatonin. On 10 April, blood samples to be assayed for LH were collected at 10-min intervals over 4h (starting at 09:00 and 22:00 h). After samples 6 and 18 were… CONTINUE READING

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