Effects of age on tissues and regions of the cerebrum and cerebellum

  title={Effects of age on tissues and regions of the cerebrum and cerebellum},
  author={Terry L. Jernigan and Sarah L. Archibald and Christine Fennema-Notestine and Anthony Collins Gamst and J C Stout and Julie Bonner and J.R. Hesselink},
  journal={Neurobiology of Aging},

In vivo evidence of cerebellar atrophy and cerebral white matter loss in Huntington disease

The cerebellum and the integrity of cerebral white matter may play a more significant role in the symptomatology of HD than previously thought and changes in cortical gray and cerebralwhite matter were related to caudate atrophy, supporting a similar mechanism of degeneration.

The effect of sex and age on cortical grey and white matter volumes of frontal lobe

Findings confirm the continuation of maturation of frontal lobe until fourth decade and sex is a major contributor to GMV and WMV differences between individuals.

Gray Matter Atrophy in the Cerebellum—Evidence of Increased Vulnerability of the Crus and Vermis with Advancing Age

Analysis of cerebellar volumetric gray matter loss across the adult lifespan in a large cross-sectional sample confirmed that regionally specific GM loss occurs in the cerebellum with age, and form a solid base for further investigation to find functional correlates for this global and focal loss.

One-Year Brain Atrophy Evident in Healthy Aging

MRI studies suggest that the changes in the brain in healthy aging are not primarily driven by degenerative processes associated with AD, although it is likely that preclinical changes associated withAD are superposed on changes due to normal aging in some subjects, especially in the temporal lobes.

Gray-matter macrostructure in cognitively healthy older persons: associations with age and cognition

A deeper understanding of brain macrostructure and its associations with cognition in persons who are considered cognitively healthy is critical to the early detection of persons at risk of

Effects of age and sex on volumes of the thalamus, pons, and cortex

Age effect on subcortical structures in healthy adults




Age-related decline in MRI volumes of temporal lobe gray matter but not hippocampus

Cerebral structure on MRI, Part I: Localization of age-related changes

Age-related differences in volumes of subcortical nuclei, brain matter, and cerebrospinal fluid in healthy men as measured with magnetic resonance imaging.

Of brain regions affected, the caudate and lenticular nuclei are significantly more affected by healthy aging than is cerebral brain matter; this may account for some of the motor abnormalities in aging.

Selective aging of the human cerebral cortex observed in vivo: differential vulnerability of the prefrontal gray matter.

Small but consistent rightward asymmetry was found in the whole cerebral hemispheres, superior parietal, fusiform and orbito-frontal cortices, postcentral and prefrontal white matter, and in the parietal white matter.

Interactive effects of age and hypertension on volumes of brain structures.

Temporal and occipital regions appear most vulnerable to brain atrophy due to the interactive effects of age and hypertension, and Hypertension exacerbates the morphological changes accompanying advanced age.

White matter changes with normal aging

The finding of a highly significant decrease with age in white matter, in the absence of a substantial decrease in gray matter, is consistent with recent neuropathologic reports in humans and nonhuman primates.

Quantitative cerebral anatomy of the aging human brain

Many elderly subjects did not exhibit cortical atrophy or lateral ventricular enlargement, however, indicating that such changes are not inevitable consequences of advancing age, and these data should provide a useful clinical context within which to interpret changes in regional brain size associated with “abnormal” aging.

A quantitative magnetic resonance imaging study of changes in brain morphology from infancy to late adulthood.

These patterns of growth and change seen in vivo with MRI are largely consistent with neuropathological studies, as well as animal models of development, and may reflect neuronal progressive and regressive processes, including cell growth, myelination, cell death, and atrophy.

Prefrontal gray and white matter volumes in healthy aging and Alzheimer disease.

It is likely that AD is different from accelerated aging, as both gray and white matter loss contribute to the decline of prefrontal volume and the gray-white matter ratio that does not differ between YHE and subjects with AD.

Sex differences in brain aging: a quantitative magnetic resonance imaging study.

The results are generally consistent with the few published studies on sex differences in brain aging and suggest that, for at least some structures, aging effects may be more apparent in men than women.