Effects of age on levels of cysteine, glutathione and related enzyme activities in livers of mice and rats and an attempt to replenish hepatic glutathione level of mouse with cysteine derivatives

@article{Nakata1996EffectsOA,
  title={Effects of age on levels of cysteine, glutathione and related enzyme activities in livers of mice and rats and an attempt to replenish hepatic glutathione level of mouse with cysteine derivatives},
  author={K. Nakata and M. Kawase and Shinya Ogino and Chieko Kinoshita and Hideaki Murata and T. Sakaue and K. Ogata and S. Ohmori},
  journal={Mechanisms of Ageing and Development},
  year={1996},
  volume={90},
  pages={195-207}
}
There was a large statistically significant decrease in the hepatic level of cysteine and glutathione (GSH) in 24 month-old mice compared to young mice, while, cystine and glutathione disulfide (GSSG) contents in the liver did not differ between young and old mice. Activities of cystathionine gamma-lyase and beta-synthase in mouse liver of the 24 month-old group were significantly decreased. In rats, the hepatic levels of cysteine, cystine, GSH and GSSG exhibited no statistically significant… Expand
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