Effects of age and sex on ketamine anaesthesia in the rat.

Abstract

Intraperitoneal injections of ketamine 75 mg kg-1 in rats of both sexes (age 1--16 weeks) revealed a significant relationship between increased age and decreased duration of sleeping time for both sexes during the first 3 weeks of age. This decrease in sleeping time seemed to be associated with the increased production of the cyclohexanone oxidation metabolite of ketamine. After 3 weeks of age there was a greater sleeping time in the female rat than the male and this seemed to be associated with a greater ability of the male to produce the cyclohexanone oxidation metabolite.

Cite this paper

@article{Waterman1978EffectsOA, title={Effects of age and sex on ketamine anaesthesia in the rat.}, author={A. E. Waterman and Asher Livingston}, journal={British journal of anaesthesia}, year={1978}, volume={50 9}, pages={885-9} }