Effects of age and insulin-like growth factor-1 on neuron and synapse numbers in area CA3 of hippocampus

@article{Poe2001EffectsOA,
  title={Effects of age and insulin-like growth factor-1 on neuron and synapse numbers in area CA3 of hippocampus},
  author={Brandon Hollis Poe and Cole R. Linville and David Ray Riddle and William Edmund Sonntag and Judy Karen Brunso-Bechtold},
  journal={Neuroscience},
  year={2001},
  volume={107},
  pages={231-238}
}
Age-related effects associated with the hippocampus include declines in numbers of neurons and synapses in the dentate gyrus and area CA1, and decreased cognitive ability as assessed with the Morris water maze. The present study quantified both neuron and synapse number in the same tissue block of area CA3 of the hippocampus. No investigations of both density of neurons and synapses together in area CA3 of hippocampus have been performed previously, despite its importance as the terminal field… CONTINUE READING
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