Effects of age and dietary antioxidants on cerebral electron transport chain activity.

@article{Sharman2001EffectsOA,
  title={Effects of age and dietary antioxidants on cerebral electron transport chain activity.},
  author={Edward H Sharman and Stephen C Bondy},
  journal={Neurobiology of aging},
  year={2001},
  volume={22 4},
  pages={629-34}
}
Aging is a pleiotropic process involving genetic and environmental factors. Recently it has been demonstrated that dietary constituents may affect senescence. In the present study, adult (3 month-old) mice were fed diets supplemented with ubiquinone (coenzyme Q(10)), alpha-lipoic acid, melatonin or alpha-tocopherol for a six-month period to determine if antioxidants may reverse or inhibit the progression of certain age-associated changes in cerebral mitochondrial electron transport chain (ETS… CONTINUE READING

Connections & Topics

Mentioned Connections BETA
In the present study , adult ( 3 month - old ) mice were fed diets supplemented with ubiquinone ( coenzyme Q(10 ) ) , alpha - lipoic acid , melatonin or alpha - tocopherol for a six - month period to determine if antioxidants may reverse or inhibit the progression of certain age - associated changes in cerebral mitochondrial electron transport chain ( ETS ) enzyme activities .
In the present study , adult ( 3 month - old ) mice were fed diets supplemented with ubiquinone ( coenzyme Q(10 ) ) , alpha - lipoic acid , melatonin or alpha - tocopherol for a six - month period to determine if antioxidants may reverse or inhibit the progression of certain age - associated changes in cerebral mitochondrial electron transport chain ( ETS ) enzyme activities .
In the present study , adult ( 3 month - old ) mice were fed diets supplemented with ubiquinone ( coenzyme Q(10 ) ) , alpha - lipoic acid , melatonin or alpha - tocopherol for a six - month period to determine if antioxidants may reverse or inhibit the progression of certain age - associated changes in cerebral mitochondrial electron transport chain ( ETS ) enzyme activities .
In the present study , adult ( 3 month - old ) mice were fed diets supplemented with ubiquinone ( coenzyme Q(10 ) ) , alpha - lipoic acid , melatonin or alpha - tocopherol for a six - month period to determine if antioxidants may reverse or inhibit the progression of certain age - associated changes in cerebral mitochondrial electron transport chain ( ETS ) enzyme activities .
However , this enzyme complex was elevated , in animals supplemented with coenzyme Q(10 ) , alpha - lipoic acid and alpha - tocopherol , above corresponding values obtained with basal diet .
However , this enzyme complex was elevated , in animals supplemented with coenzyme Q(10 ) , alpha - lipoic acid and alpha - tocopherol , above corresponding values obtained with basal diet .
In the present study , adult ( 3 month - old ) mice were fed diets supplemented with ubiquinone ( coenzyme Q(10 ) ) , alpha - lipoic acid , melatonin or alpha - tocopherol for a six - month period to determine if antioxidants may reverse or inhibit the progression of certain age - associated changes in cerebral mitochondrial electron transport chain ( ETS ) enzyme activities .
In the present study , adult ( 3 month - old ) mice were fed diets supplemented with ubiquinone ( coenzyme Q(10 ) ) , alpha - lipoic acid , melatonin or alpha - tocopherol for a six - month period to determine if antioxidants may reverse or inhibit the progression of certain age - associated changes in cerebral mitochondrial electron transport chain ( ETS ) enzyme activities .
In the present study , adult ( 3 month - old ) mice were fed diets supplemented with ubiquinone ( coenzyme Q(10 ) ) , alpha - lipoic acid , melatonin or alpha - tocopherol for a six - month period to determine if antioxidants may reverse or inhibit the progression of certain age - associated changes in cerebral mitochondrial electron transport chain ( ETS ) enzyme activities .
In the present study , adult ( 3 month - old ) mice were fed diets supplemented with ubiquinone ( coenzyme Q(10 ) ) , alpha - lipoic acid , melatonin or alpha - tocopherol for a six - month period to determine if antioxidants may reverse or inhibit the progression of certain age - associated changes in cerebral mitochondrial electron transport chain ( ETS ) enzyme activities .
In the present study , adult ( 3 month - old ) mice were fed diets supplemented with ubiquinone ( coenzyme Q(10 ) ) , alpha - lipoic acid , melatonin or alpha - tocopherol for a six - month period to determine if antioxidants may reverse or inhibit the progression of certain age - associated changes in cerebral mitochondrial electron transport chain ( ETS ) enzyme activities .
However , this enzyme complex was elevated , in animals supplemented with coenzyme Q(10 ) , alpha - lipoic acid and alpha - tocopherol , above corresponding values obtained with basal diet .
In the present study , adult ( 3 month - old ) mice were fed diets supplemented with ubiquinone ( coenzyme Q(10 ) ) , alpha - lipoic acid , melatonin or alpha - tocopherol for a six - month period to determine if antioxidants may reverse or inhibit the progression of certain age - associated changes in cerebral mitochondrial electron transport chain ( ETS ) enzyme activities .
In the present study , adult ( 3 month - old ) mice were fed diets supplemented with ubiquinone ( coenzyme Q(10 ) ) , alpha - lipoic acid , melatonin or alpha - tocopherol for a six - month period to determine if antioxidants may reverse or inhibit the progression of certain age - associated changes in cerebral mitochondrial electron transport chain ( ETS ) enzyme activities .
However , this enzyme complex was elevated , in animals supplemented with coenzyme Q(10 ) , alpha - lipoic acid and alpha - tocopherol , above corresponding values obtained with basal diet .
In the present study , adult ( 3 month - old ) mice were fed diets supplemented with ubiquinone ( coenzyme Q(10 ) ) , alpha - lipoic acid , melatonin or alpha - tocopherol for a six - month period to determine if antioxidants may reverse or inhibit the progression of certain age - associated changes in cerebral mitochondrial electron transport chain ( ETS ) enzyme activities .
In the present study , adult ( 3 month - old ) mice were fed diets supplemented with ubiquinone ( coenzyme Q(10 ) ) , alpha - lipoic acid , melatonin or alpha - tocopherol for a six - month period to determine if antioxidants may reverse or inhibit the progression of certain age - associated changes in cerebral mitochondrial electron transport chain ( ETS ) enzyme activities .
In the present study , adult ( 3 month - old ) mice were fed diets supplemented with ubiquinone ( coenzyme Q(10 ) ) , alpha - lipoic acid , melatonin or alpha - tocopherol for a six - month period to determine if antioxidants may reverse or inhibit the progression of certain age - associated changes in cerebral mitochondrial electron transport chain ( ETS ) enzyme activities .
In the present study , adult ( 3 month - old ) mice were fed diets supplemented with ubiquinone ( coenzyme Q(10 ) ) , alpha - lipoic acid , melatonin or alpha - tocopherol for a six - month period to determine if antioxidants may reverse or inhibit the progression of certain age - associated changes in cerebral mitochondrial electron transport chain ( ETS ) enzyme activities .
In the present study , adult ( 3 month - old ) mice were fed diets supplemented with ubiquinone ( coenzyme Q(10 ) ) , alpha - lipoic acid , melatonin or alpha - tocopherol for a six - month period to determine if antioxidants may reverse or inhibit the progression of certain age - associated changes in cerebral mitochondrial electron transport chain ( ETS ) enzyme activities .
NADH - ubiquinone oxidoreductase ( Complex I ) and ubiquinol : ferricytochrome - c oxidoreductase ( Complex III ) activities remained unchanged .
All Topics