Effects of aflatoxin B1 on murine lymphocytic functions.

  title={Effects of aflatoxin B1 on murine lymphocytic functions.},
  author={Rajasekhar V. Reddy and Raghubir P. Sharma},
  volume={54 1},
We recently reported on the immunotoxic effects of Aflatoxin B1 (AFB1), a secondary fungal metabolite of Aspergillus flavus in mice. The present paper describes the effect of AFB1 on cellular functions in lymphocytes after in vivo or in vitro exposures. Male BALB/c mice received 0, 0.03, 0.145 or 0.7 mg/kg body weight of AFB1 for 4 weeks. A dose-related decrease in DNA synthesis in lymphocyte cultures with or without the mitogens (lipopolysaccharide, phytohemagglutinin, pokeweed mitogen and… CONTINUE READING
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