Effects of aerosolized methylprednisolone on experimental neurogenic pulmonary injury.

@article{Edmonds1986EffectsOA,
  title={Effects of aerosolized methylprednisolone on experimental neurogenic pulmonary injury.},
  author={H. Edmonds and H. Cannon and H. Garretson and G. Dahlquist},
  journal={Neurosurgery},
  year={1986},
  volume={19 1},
  pages={
          36-40
        }
}
We examined the effects of graded doses of methylprednisolone sodium succinate (MPSS)--0.05 (low), 0.5 (medium), and 5 mg/kg/hour (high)--on the development of neurogenic pulmonary injury in rabbits. The aerosolized drug was administered intratracheally for 5 hours beginning 10 minutes after a 2-minute elevation of the cerebrospinal fluid pressure (Pcsf) to 250 mm Hg. Compared to untreated control animals, the percentage of increase in pulmonary capillary permeability, as determined by 51Cr… Expand
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