Effects of advanced selection methods on sperm quality and ART outcome: a systematic review.

@article{Said2011EffectsOA,
  title={Effects of advanced selection methods on sperm quality and ART outcome: a systematic review.},
  author={Tamer M. Said and Jolande A. Land},
  journal={Human reproduction update},
  year={2011},
  volume={17 6},
  pages={
          719-33
        }
}
  • T. SaidJ. Land
  • Published 1 November 2011
  • Medicine
  • Human reproduction update
BACKGROUND Current routine semen preparation techniques do not inclusively target all intrinsic sperm characteristics that may impact the fertilization potential. In order to address these characteristics, several methods have been recently developed and applied to sperm selection. The objective of this study was to systematically review the literature describing these advanced sperm selection methods focusing on their anticipated benefits on sperm quality and assisted reproductive technique… 

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References

SHOWING 1-10 OF 98 REFERENCES

Evaluation of sperm selection procedure based on hyaluronic acid binding ability on ICSI outcome

The results suggest that normal sperm have higher chance to bind HA and therefore, HA sperm selection procedure may select sperm with normal protamine content and low DNA fragmentation, but to confirm the effect ofHA sperm selection on the ICSI outcome requires further studies.

Real-time fine morphology of motile human sperm cells is associated with IVF-ICSI outcome.

Findings indicate that ICSI-associated pregnancy rate may be affected by subtle morphological malformations of the sperm nucleus, which may remain undetected by the embryologist during the routine selection procedure.

Sperm head's birefringence: a new criterion for sperm selection.

Selection of sperm based on combined density gradient and Zeta method may improve ICSI outcome.

Combining DGC and Zeta procedures improves the quality of semen samples which may increase fertilization rates and possibly pregnancy rates.

How to improve IVF-ICSI outcome by sperm selection.

Prospective controlled trial of an electrophoretic method of sperm preparation for assisted reproduction: comparison with density gradient centrifugation.

This pilot study demonstrates that membrane-based electrophoresis is as effective as DGC in preparing sperm for IVF and ICSI, although it takes only a fraction of the time.

Relationship between hyaluronic acid binding assay and outcome in ART: a pilot study

HBA outcome improved after sperm preparation and culture, but was not correlated to detailed sperm morphology, concentration or motility, and the clinical value for HBA in addition to routine semen analysis for this patient population seems limited.

Utility of magnetic cell separation as a molecular sperm preparation technique.

Results clearly indicate that integrating MACS as a part of sperm preparation techniques will improve semen quality and cryosurvival rates by eliminating apoptotic sperm.

The role of sperm morphology in assisted reproduction.

The evaluation of sperm morphology by strict criteria is a simple, cost-effective method and can be used to guide the clinician and scientist on a day-to-day basis to make sound clinical decisions.
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