Effects of advanced glycation end products on cytosolic Ca2+ signaling of cultured human mesangial cells.

@article{Men1999EffectsOA,
  title={Effects of advanced glycation end products on cytosolic Ca2+ signaling of cultured human mesangial cells.},
  author={Paolo Men{\`e} and Combes Motel Pascale and Alessandro Teti and Silvia Bernardini and Giulio A. Cinotti and Francesco Pugliese},
  journal={Journal of the American Society of Nephrology : JASN},
  year={1999},
  volume={10 7},
  pages={
          1478-86
        }
}
Advanced glycation end product (AGE) accumulation in a high glucose (HG) environment is thought to mediate some of the vascular complications of diabetes. Transmembrane signaling of contractile cells is generally inhibited by HG, with implications for systemic and target organ hemodynamics. In the kidney, glomerular mesangial cells grown in HG media are hyporesponsive to the effects of vasoconstrictor agents, possibly explaining the hyperfiltration and increased capillary pressure that… CONTINUE READING

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