Effects of adrenomedullin on systolic and diastolic myocardial function.

  title={Effects of adrenomedullin on systolic and diastolic myocardial function.},
  author={Ana Patr{\'i}cia N Fontes-Sousa and Ana Lu{\'i}sa Pires and Catarina Santos Carneiro and C{\'a}rmen Br{\'a}s-Silva and Adelino F Leite-Moreira},
  volume={30 4},
Adrenomedullin (AM) effects were studied in rabbit papillary muscles by adding increasing concentrations (10(-10) to 10(-6)M) either alone or after pre-treatment with l-NNA, indomethacin, AM22-52 (AM receptor antagonist), CGRP(8-37) (CGRP receptors antagonist), KT5720 (PKA inhibitor), as well as after endocardial endothelium (EE) removal. Passive length-tension relations were constructed before and after a single concentration of AM (10(-6)M). AM concentration-dependently induced negative… CONTINUE READING