Effects of adrenomedullin on cyclic AMP formation and on relaxation in iris sphincter smooth muscle.

@article{Yousufzai1999EffectsOA,
  title={Effects of adrenomedullin on cyclic AMP formation and on relaxation in iris sphincter smooth muscle.},
  author={Sardar Y. K. Yousufzai and Noorjahan Ali and A A Abdel-latif},
  journal={Investigative ophthalmology & visual science},
  year={1999},
  volume={40 13},
  pages={3245-53}
}
PURPOSE To determine whether iris sphincter and other tissues of the iris-ciliary body secrete adrenomedullin (ADM), a novel hypotensive peptide that is classified into the calcitonin gene-related peptide (CGRP) family and to determine the binding sites for ADM and compare the effects of ADM and CGRP in the absence and presence of their receptor antagonists on cAMP formation and relaxation in the iris sphincter. METHODS Sphincter muscle was incubated in Krebs-Ringer bicarbonate buffer in the… CONTINUE READING