Effects of adrenergic and cholinergic agents upon insulin secretion in vitro.

  title={Effects of adrenergic and cholinergic agents upon insulin secretion in vitro.},
  author={Willy J Malaisse and Francine Malaisse-Lagae and Peter H. Wright and James Ashmore},
  volume={80 5},
Adrenergic drugs (epinephrine, norepinephrine and isoproterenol) inhibit insulin secretion from pieces of rat pancreas incubated with glucose (150 mg/100 ml). This inhibitory effect appears to be mediated through alphareceptors for it is blocked by alpha- but little affected by beta-blocking agents. Cholinergic drugs (acetyl choline and carbamyl choline) have a stimulant effect using media containing glucose in low concentrations (100 mg/100 ml), and this effect is suppressed by simultaneous… Expand
Effect of epinephrine and norepinephrine on immuno-reactive insulin secretion from isolated islets of Langerhans.
Results show that epinephrine and norepinephrine inhibit islet-IRI release at the 100-10 microM level, which clearly suggests that epi-adrenergic inhibition of insulin release via alpha- adrenergic pathway. Expand
Effect of corticosterone on insulin and glucagon secretion by the isolated perfused rat pancreas.
The present results demonstrate that corticosterone has direct effects on pancreatic islet cells, and they suggest that the inhibition of insulin secretion is to some extent related to the alpha-adrenergic receptors. Expand
Inhibition of pancreatic islet monoamine oxidase by adrenergic antagonists and ethanol.
  • J. Feldman
  • Chemistry, Medicine
  • Endocrine research communications
  • 1975
It is concluded that inhibition of islet MAO may cause an increase in islet monoamine content and these monoamines may alter in vitro insulin secretion. Expand
Sympathetic regulation of insulin secretion. Its relation to diabetes mellitus.
  • D. Porte
  • Medicine
  • Archives of internal medicine
  • 1969
It is postulated that the catecholamine release which is stimulated by volume depletion, infection, or stress may be an important "reversible" factor in some patients with diabetic ketoacidosis. Expand
Adrenergic changes due to pertussis: insulin, glucose and free fatty acids.
Pertussis appears to enhance the β-agonist responsiveness insofar as insulin is concerned, and it is suggested that pertussis reverses epinephrine-induced insulin suppression. Expand
Effects of alpha-adrenoceptor agonists and antagonists on insulin secretion, calcium uptake, and rubidium efflux in mouse pancreatic islets.
It is concluded that insulin secretion is suppressed by alpha-2 receptor agonism in the pancreatic beta-cells and that this effect is mediated by mechanisms other than the transmembrane fluxes of calcium or potassium ions. Expand
Adrenergic receptors and the secretion of glucagon and insulin from the isolated, perfused canine pancreas.
  • J. Iversen
  • Chemistry, Medicine
  • The Journal of clinical investigation
  • 1973
Evidence is presented that both the alpha cells and the bet cells are under the influence of adrenergic substances, the stimulation of glucagon release beingmediated through a beta receptor and the inhibition of insulin release being mediated through an alpha receptor. Expand
Ethanol influence on insulin secretion from isolated rat islets
The data suggest that the site of action of the deleterious effects of ethanol on insulin release from isolated islets in rat does not involve adrenergic system and cyclic AMP. Expand
Extracellular Calcium and Acetylcholine-stimulated Insulin Secretion
It is concluded that acetylcholine-stimulated insulin secretion is dependent upon extracellular Ca++ and an increase in Ca++ influx may be involved in this stimulation. Expand
Glucagon and Insulin Release: Influence of Drugs Affecting the Autonomic Nervous System
The results suggested that neither autonomic nervous system compounds or the adenylcyclase system directly affect IRG release, and the physiolugical significance of the direct inhibitory effect of substances with alpha adrenergic properties on IRI release is questioned. Expand


Drug Dosage in Laboratory Animals
Drug Dosage in Laboratory AnimalsA Handbook. By C. D. Barnes and L. G. Eltherington. Pp. 302. (Berkeley and Los Angeles: University of California Press; London: Cambridge University Press, 1964.) 64s.