Effects of adrenergic and cholinergic agents upon insulin secretion in vitro.

@article{Malaisse1967EffectsOA,
  title={Effects of adrenergic and cholinergic agents upon insulin secretion in vitro.},
  author={Willy J Malaisse and Francine Malaisse-Lagae and Peter H. Wright and James Ashmore},
  journal={Endocrinology},
  year={1967},
  volume={80 5},
  pages={
          975-8
        }
}
Adrenergic drugs (epinephrine, norepinephrine and isoproterenol) inhibit insulin secretion from pieces of rat pancreas incubated with glucose (150 mg/100 ml). This inhibitory effect appears to be mediated through alphareceptors for it is blocked by alpha- but little affected by beta-blocking agents. Cholinergic drugs (acetyl choline and carbamyl choline) have a stimulant effect using media containing glucose in low concentrations (100 mg/100 ml), and this effect is suppressed by simultaneous… Expand
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