Effects of adenosine on human coronary arterial circulation.

@article{Wilson1990EffectsOA,
  title={Effects of adenosine on human coronary arterial circulation.},
  author={Robert F. Wilson and Keith Wyche and Betsy V. Christensen and Sebastian Zimmer and David D. Laxson},
  journal={Circulation},
  year={1990},
  volume={82 5},
  pages={
          1595-606
        }
}
Adenosine is a potent vasodilator used extensively to study the coronary circulation of animals. Its use in humans, however, has been hampered by lack of knowledge about its effects on the human coronary circulation and by concern about its safety. We investigated in humans the effects of adenosine, administered by intracoronary bolus (2-16 micrograms), intracoronary infusion (10-240 micrograms/min), or intravenous infusion (35-140 micrograms/kg/min) on coronary and systemic hemodynamics and… 

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