Effects of adenosine on human coronary arterial circulation.

  title={Effects of adenosine on human coronary arterial circulation.},
  author={Robert F. Wilson and Keith Wyche and Betsy V. Christensen and Sebastian Zimmer and David D. Laxson},
  volume={82 5},
Adenosine is a potent vasodilator used extensively to study the coronary circulation of animals. Its use in humans, however, has been hampered by lack of knowledge about its effects on the human coronary circulation and by concern about its safety. We investigated in humans the effects of adenosine, administered by intracoronary bolus (2-16 micrograms), intracoronary infusion (10-240 micrograms/min), or intravenous infusion (35-140 micrograms/kg/min) on coronary and systemic hemodynamics and… 

Figures and Tables from this paper

Effect of adenosine triphosphate on human coronary circulation.

It is suggested that maximal coronary vasodilation can be achieved safely with intracoronary ATP administration and that intravenous infusions at 150 microg/kg/min cause near-maximal coronary hyperemia in most patients.

Mechanisms of adenosine-induced epicardial coronary artery dilatation.

A significant correlation exists between epicardial coronary vasodilation and coronary blood flow velocity during intracoronary adenosine infusion, thus suggesting that epicardials coronary Vasodilation induced byAdenosine is predominantly flow-mediated rather than direct.

Pharmacological stress with adenosine for myocardial perfusion imaging.

  • M. Verani
  • Medicine, Biology
    Seminars in nuclear medicine
  • 1991

Theophylline increases coronary vascular tone in humans: evidence for a role of endogenous adenosine in flow regulation.

The hypothesis that endogenous adenosine is involved in regulation of human coronary tone is supported.

Adenosine 5'-triphosphate induced dilation of human coronary microvessels in vivo.

The results suggest that ATP induces maximal dilation of coronary microvessels, most likely through an endothelium-independent mechanism, and conclude that coronary flow reserve can be determined safely with intracoronary ATP administration.

Effects of selective alpha1- and alpha2-adrenergic blockade on coronary flow reserve after coronary stenting.

Urapidil and yohimbine attenuated the CFR impairment occurring after revascularization by increasing both the epicardial vasodilator effect of adenosine and the blood flow velocity, thus suggesting that the adrenergic system plays an important role in limiting the capacity of the coronary circulation to dilate.



Effect of adenosine on transmural myocardial blood flow distribution in the awake dog.

The data indicate that maximal vasodilatory doses of adenosine have little effect on the endocardial-to-epicardial blood flow ratio, whereas submaximal doses result in a marked preferential endocardia perfusion, which was not altered by hyperoxia.

Value and limitations of intracoronary adenosine for the assessment of coronary flow reserve.

Intracoronary adenosine is a potent and very short acting vasodilator for studying coronary flow reserve, but the side effects and unpredictability of the dosage needed to produce maximal hyperemia may limit its applicability.

Responsiveness to Cardiac Sympathetic Nerve Stimulation During Maximal Coronary Dilation Produced by Adenosine

It is indicated that coronary arteries maximally dilated with adenosine are responsive to constrictor effects of adrenergic and nonadrenergic stimuli, and that duringAdenosine treatment, the administration of angiotensin, phenylephrine, norepinephrine, and tyramine decreases both endocardial and epicardial flow, but sympathetic nerve stimulation decreases epicardia flow without significant decreases in endocardia flow.

Intracoronary papaverine: an ideal coronary vasodilator for studies of the coronary circulation in conscious humans.

This study used a subselective coronary Doppler catheter to measure the dose-response kinetics of a shorter acting vasodilator, intracoronary papaverine, and found that at maximal hyperemia, mean arterial blood pressure fell 9 +/- 2% after intracornary papaversine, 8 +/- 4% after dipyridamole, and 3 +/- 3% after meglumine diatrizoate.

Reflex increase in blood pressure during the intracoronary administration of adenosine in man.

Fusion of adenosine into the LAD coronary artery causes a reflex increase in arterial pressure due to a rise in systemic vascular resistance, probably as a result of increased sympathetic discharge, which may be of importance in disease states such as myocardial ischemia.

Conditions for Vasodilator-induced Coronary Steal in Experimental Myocardial Ischemia

coronary steal appears to require 1) an arteriolartype dilator like dipyridamole and 2) stenoses of the arteries supplying collateral flow to the ischemic region, resulting in reduced driving pressure for collateral flow.

Transluminal, subselective measurement of coronary artery blood flow velocity and vasodilator reserve in man.

The developed and validated a small Doppler catheter that can subselectively measure phasic coronary blood flow velocity (CBFV) and assessing vasodilator reserve in the catheterization laboratory should facilitate studies of the coronary circulation in man.

Inhibition of Coronary Vasodilating Action of Dipyridamole and Adenosine by Aminophylline in the Dog

  • S. Afonso
  • Medicine, Chemistry
    Circulation research
  • 1970
Intravenous aminophylline was found to inhibit coronary vasodilatation induced by intravenous or intracoronary dipyridamole or adenosine.

Effect of theophylline on adenosine production in the canine myocardium.

The failure of theophylline to attenuate isoproterenol hyperemia in the dog heart results at least in part from an increase in adenosine concentration at the arteriole to a level beyond that blocked by this competitive antagonist.

Coronary Vasoactivity of Adenosine in the Conscious Dog

The hydrophobicity of these analogs did not correlate with vasoactivity, suggesting that the hydrophilicity of the ribose moiety overshadows any hydrophobic influence of the very weakly aromatic purine base.