Effects of adenosine on human coronary arterial circulation.

@article{Wilson1990EffectsOA,
  title={Effects of adenosine on human coronary arterial circulation.},
  author={R. Wilson and K. Wyche and B. V. Christensen and S. Zimmer and D. Laxson},
  journal={Circulation},
  year={1990},
  volume={82 5},
  pages={
          1595-606
        }
}
Adenosine is a potent vasodilator used extensively to study the coronary circulation of animals. Its use in humans, however, has been hampered by lack of knowledge about its effects on the human coronary circulation and by concern about its safety. We investigated in humans the effects of adenosine, administered by intracoronary bolus (2-16 micrograms), intracoronary infusion (10-240 micrograms/min), or intravenous infusion (35-140 micrograms/kg/min) on coronary and systemic hemodynamics and… Expand

Paper Mentions

Interventional Clinical Trial
This is a single centre, prospective diagnostic accuracy study to assess the comparative sensitivity of dobutamine versus adenosine for detection of severe non-infarct epicardial… Expand
ConditionsCardiac MRI, Coronary Artery Disease, Heart Failure
InterventionDiagnostic Test
Effect of adenosine triphosphate on human coronary circulation.
TLDR
It is suggested that maximal coronary vasodilation can be achieved safely with intracoronary ATP administration and that intravenous infusions at 150 microg/kg/min cause near-maximal coronary hyperemia in most patients. Expand
Mechanisms of adenosine-induced epicardial coronary artery dilatation.
TLDR
A significant correlation exists between epicardial coronary vasodilation and coronary blood flow velocity during intracoronary adenosine infusion, thus suggesting that epicardials coronary Vasodilation induced byAdenosine is predominantly flow-mediated rather than direct. Expand
The effect of rapid decreases of blood pressure by different mechanisms on coronary flow and flow reserve in normal coronary arteries.
TLDR
In normal coronary arteries the infusion of three hypotensive medications to produce the same decreases in MBP is associated with different effects on CFR (increase with clonidine, decrease with nitroprusside, and no change with nitroglycerin). Expand
Safety and optimal dose of intracoronary adenosine 5'-triphosphate for the measurement of coronary flow reserve.
TLDR
These results suggest that maximal coronary vasodilation in the left coronary artery can be safely obtained with doses > or = 15 microg of intracoronary ATP in patients with normal coronary arteries. Expand
Pharmacological stress with adenosine for myocardial perfusion imaging.
  • M. Verani
  • Medicine
  • Seminars in nuclear medicine
  • 1991
TLDR
Adenosine is a ubiquitous purine base that has many physiological actions in the body, including arterial vasodilation in all vascular beds, with the exception of the kidneys, and requires a continuous intravenous infusion for its use. Expand
Isolated defect of adenosine-mediated coronary vasodilation: functional evidence for a new microangiopathic entity.
TLDR
These findings are consistent with functional evidence for a new entity of a coronary microangiopathy affecting a subtype of the endothelium-independent vasomotion. Expand
Theophylline increases coronary vascular tone in humans: evidence for a role of endogenous adenosine in flow regulation.
TLDR
The hypothesis that endogenous adenosine is involved in regulation of human coronary tone is supported. Expand
Adenosine 5'-triphosphate induced dilation of human coronary microvessels in vivo.
TLDR
The results suggest that ATP induces maximal dilation of coronary microvessels, most likely through an endothelium-independent mechanism, and conclude that coronary flow reserve can be determined safely with intracoronary ATP administration. Expand
Effects of intravenous and intracoronary adenosine 5'-triphosphate as compared with adenosine on coronary flow and pressure dynamics.
TLDR
Step up in dosage of ATP and adenosine beyond currently recommended clinical doses resulted in a significant increase in coronary hyperemia, and ATP was equivalent toadenosine for both CFR and FFR; and complete coronary occlusion yielded a better hyperemic response than either drug, indicating that maximal hype Remia was not achieved by either pharmacological stimulus. Expand
Comparison of coronary vasodilation with intravenous dipyridamole and adenosine.
Although both intravenous dipyridamole and adenosine have been used to produce coronary vasodilation during cardiac imaging, the relative potency of the commonly administered doses of these agentsExpand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 50 REFERENCES
Effect of adenosine on transmural myocardial blood flow distribution in the awake dog.
TLDR
The data indicate that maximal vasodilatory doses of adenosine have little effect on the endocardial-to-epicardial blood flow ratio, whereas submaximal doses result in a marked preferential endocardia perfusion, which was not altered by hyperoxia. Expand
Value and limitations of intracoronary adenosine for the assessment of coronary flow reserve.
TLDR
Intracoronary adenosine is a potent and very short acting vasodilator for studying coronary flow reserve, but the side effects and unpredictability of the dosage needed to produce maximal hyperemia may limit its applicability. Expand
Responsiveness to Cardiac Sympathetic Nerve Stimulation During Maximal Coronary Dilation Produced by Adenosine
TLDR
It is indicated that coronary arteries maximally dilated with adenosine are responsive to constrictor effects of adrenergic and nonadrenergic stimuli, and that duringAdenosine treatment, the administration of angiotensin, phenylephrine, norepinephrine, and tyramine decreases both endocardial and epicardial flow, but sympathetic nerve stimulation decreases epicardia flow without significant decreases in endocardia flow. Expand
Intracoronary papaverine: an ideal coronary vasodilator for studies of the coronary circulation in conscious humans.
TLDR
This study used a subselective coronary Doppler catheter to measure the dose-response kinetics of a shorter acting vasodilator, intracoronary papaverine, and found that at maximal hyperemia, mean arterial blood pressure fell 9 +/- 2% after intracornary papaversine, 8 +/- 4% after dipyridamole, and 3 +/- 3% after meglumine diatrizoate. Expand
Reflex increase in blood pressure during the intracoronary administration of adenosine in man.
TLDR
Fusion of adenosine into the LAD coronary artery causes a reflex increase in arterial pressure due to a rise in systemic vascular resistance, probably as a result of increased sympathetic discharge, which may be of importance in disease states such as myocardial ischemia. Expand
Conditions for Vasodilator-induced Coronary Steal in Experimental Myocardial Ischemia
TLDR
coronary steal appears to require 1) an arteriolartype dilator like dipyridamole and 2) stenoses of the arteries supplying collateral flow to the ischemic region, resulting in reduced driving pressure for collateral flow. Expand
Transluminal, subselective measurement of coronary artery blood flow velocity and vasodilator reserve in man.
TLDR
The developed and validated a small Doppler catheter that can subselectively measure phasic coronary blood flow velocity (CBFV) and assessing vasodilator reserve in the catheterization laboratory should facilitate studies of the coronary circulation in man. Expand
Inhibition of Coronary Vasodilating Action of Dipyridamole and Adenosine by Aminophylline in the Dog
TLDR
Intravenous aminophylline was found to inhibit coronary vasodilatation induced by intravenous or intracoronary dipyridamole or adenosine. Expand
Effect of theophylline on adenosine production in the canine myocardium.
TLDR
The failure of theophylline to attenuate isoproterenol hyperemia in the dog heart results at least in part from an increase in adenosine concentration at the arteriole to a level beyond that blocked by this competitive antagonist. Expand
Coronary Vasoactivity of Adenosine in the Conscious Dog
TLDR
The hydrophobicity of these analogs did not correlate with vasoactivity, suggesting that the hydrophilicity of the ribose moiety overshadows any hydrophobic influence of the very weakly aromatic purine base. Expand
...
1
2
3
4
5
...