Effects of adenosine and xanthine derivatives on breathing during acute hypoxia in the anesthetized newborn piglet.

@article{Darnall1987EffectsOA,
  title={Effects of adenosine and xanthine derivatives on breathing during acute hypoxia in the anesthetized newborn piglet.},
  author={Robert A. Darnall and Roger D Bruce},
  journal={Pediatric pulmonology},
  year={1987},
  volume={3 2},
  pages={110-6}
}
Neonates of animals and humans exhibit a paradoxical ventilatory response to hypoxia characterized by an initial increase in minute ventilation followed by a late, sustained decrease. Exogenous adenosine analogues cause respiratory depression, and the xanthine derivative aminophylline, a competitive inhibitor of adenosine receptors, decreases the amount of hypoxic ventilatory depression in the newborn piglet. Other xanthine derivative such as enprofylline are weak adenosine antagonists. The… CONTINUE READING