Effects of adenosine administration on the function and membrane composition of liver mitochondria in carbon tetrachloride-induced cirrhosis.

@article{HernndezMuoz1992EffectsOA,
  title={Effects of adenosine administration on the function and membrane composition of liver mitochondria in carbon tetrachloride-induced cirrhosis.},
  author={Rolando Hern{\'a}ndez-Mu{\~n}oz and Mauricio D{\'i}az-Mu{\~n}oz and Victoria Chagoya de S{\'a}nchez},
  journal={Archives of biochemistry and biophysics},
  year={1992},
  volume={294 1},
  pages={160-7}
}
The effect of chronic carbon tetrachloride (CCl4) administration on liver mitochondria function and the protective action of adenosine on CCl4-induced damage were assessed in rats made cirrhotic by long-term exposure to the hepatotoxin (8 weeks). The CCl4 treatment decreased the ADP-stimulated oxygen consumption, respiratory control, and ADP/O values, mainly for substrates oxidation of site I, in isolated mitochondria. This impaired mitochondrial capacity for substrate oxidation and ATP… CONTINUE READING

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