Effects of adenosine A1 and A2A receptor activation on the evoked release of glutamate from rat cerebrocortical synaptosomes.

@article{Marchi2002EffectsOA,
  title={Effects of adenosine A1 and A2A receptor activation on the evoked release of glutamate from rat cerebrocortical synaptosomes.},
  author={Mario Marchi and Luca Raiteri and Francesca Risso and Annalisa Vallarino and Andrea Bonfanti and Angela Monopoli and Ennio Ongini and Maurizio Raiteri},
  journal={British journal of pharmacology},
  year={2002},
  volume={136 3},
  pages={434-40}
}
1. The effects of adenosine A2A and A1 receptor activation on the release of glutamate were studied in rat cerebral cortex synaptosomes exposed in superfusion to adenosine receptor ligands. 2. Adenosine (0.1 microM) produced a significant potentiation of the Ca2+-dependent K+ (15 mM)-evoked [3H]-D-aspartate overflow (20.4+/-3.5%), which was blocked by A2A blocker SCH58261 (0.1 microM). At higher concentrations (10 - 1000 microM) adenosine inhibited in a DPCPX-sensitive manner the Ca2+-dependent… CONTINUE READING