Effects of additive therapy with spironolactone on proteinuria in diabetic patients already on ACE inhibitor or ARB therapy: results of a randomized, placebo-controlled, double-blind, crossover trial.


INTRODUCTION Aldosterone seems to have deleterious effects on the kidneys. Many animal studies and a few clinical trials have shown that suppression of aldosteroneby aldosterone receptor blockers ameliorates these effects. METHOD In a double-blind crossover study, patients with diabetic nephropathy who were already receiving either angiotensin converting… (More)
DOI: 10.2310/JIM.0b013e31816d78e9