Effects of adacolumn selective leukocytapheresis on plasma cytokines during active disease in patients with active ulcerative colitis.

@article{Hanai2006EffectsOA,
  title={Effects of adacolumn selective leukocytapheresis on plasma cytokines during active disease in patients with active ulcerative colitis.},
  author={Hiroyuki Hanai and Takayuki Iida and Masami Yamada and Yoshihiko Sato and Ken Takeuchi and Tatsuo Tanaka and Kenji Kondo and Masataka Kikuyama and Yasuhiko Maruyama and Yasushi Iwaoka and Akiko Nakamura and Kazuhisa Hirayama and Abby R. Saniabadi and Fumitoshi Watanabe},
  journal={World journal of gastroenterology},
  year={2006},
  volume={12 21},
  pages={3393-9}
}
AIM To investigate the relationship between ulcerative colitis (UC) clinical activity index (CAI) and circulating levels of IL-1ra, IL-10, IL-6 and IL-18. METHODS Blood levels of IL-1ra, IL-10, IL-6 and IL-18 were measured in 31 patients with active UC, the mean CAI was 11.1, ranging from 5-25; and 12 healthy individuals as controls. Patients were given granulocyte and monocyte adsorptive apheresis (GMA) with Adacolumn. Leucocytes which bear the FcgammaR and complement receptors were adsorbed… CONTINUE READING