Effects of acyl groups and ethanol ratios on lipase-catalyzed regioselective deacylation in peracylated methyl glycopyranosides

@article{Hsiao2004EffectsOA,
  title={Effects of acyl groups and ethanol ratios on lipase-catalyzed regioselective deacylation in peracylated methyl glycopyranosides},
  author={Kwo-Feng Hsiao and F Yang and Shih-Hsiung Wu and Kung-Tsung Wang},
  journal={Biotechnology Letters},
  year={2004},
  volume={17},
  pages={963-968}
}
Regioselective ethanolysis of peracylated methyl β, α-D-glucopyranoside and methyl α-D-mannopyranoside in anhydrous organic solvent (n-hexane/EtOH = 99/1) could afford 6-OH derivatives exclusively by Candida rugosa lipase (CRL). No 4 → 6 acyl migration was observed in such an anhydrous solvent system. Substrates with propanoyl groups were more reactive than… CONTINUE READING