Effects of acutely inhibiting PI3K isoforms and mTOR on regulation of glucose metabolism in vivo

@inproceedings{Smith2012EffectsOA,
  title={Effects of acutely inhibiting PI3K isoforms and mTOR on regulation of glucose metabolism in vivo},
  author={Greg C. Smith and Wee Kiat Ong and Gordon William Rewcastle and Jackie Diane Kendall and Weiping Han and P. R. Shepherd},
  booktitle={The Biochemical journal},
  year={2012}
}
In in vitro studies class-I PI3Ks (phosphoinositide 3-kinases), class-II PI3Ks and mTOR (mammalian target of rapamycin) have all been described as having roles in the regulation of glucose metabolism. The relative role each plays in the normal signalling processes regulating glucose metabolism in vivo is less clear. Knockout and knockin mouse models have provided some evidence that the class-I PI3K isoforms p110α, p110β, and to a lesser extent p110γ, are necessary for processes regulating… CONTINUE READING

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