Effects of acute versus chronic hypoxia on DNA damage responses and genomic instability.

@article{Pires2010EffectsOA,
  title={Effects of acute versus chronic hypoxia on DNA damage responses and genomic instability.},
  author={Isabel M Pires and Zuzana Bencokova and Manuela Milani and Lisa K. Folkes and Ji-liang Li and Mike R Stratford and Adrian L. Harris and Ester M Hammond},
  journal={Cancer research},
  year={2010},
  volume={70 3},
  pages={925-35}
}
Questions exist concerning the effects of acute versus chronic hypoxic conditions on DNA replication and genomic stability that may influence tumorigenesis. Severe hypoxia causes replication arrest independent of S-phase checkpoint, DNA damage response, or transformation status. Arrests occur during both the initiation and elongation phases of DNA… CONTINUE READING