Effects of acute tryptophan depletion on nocturnal melatonin secretion in humans.

@article{Zimmermann1993EffectsOA,
  title={Effects of acute tryptophan depletion on nocturnal melatonin secretion in humans.},
  author={Ralf C. Zimmermann and Christopher J McDougle and Michael Schumacher and James Olcese and John W. Mason and George R. Heninger and Lawrence H Price},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1993},
  volume={76 5},
  pages={
          1160-4
        }
}
Measurement of melatonin secretion throughout the night provides an index of net noradrenergic activity mediated by postsynaptic beta-adrenergic receptors in the pineal gland. Reduced melatonin secretion in some patients with depression might be related to reduced net noradrenergic function. However, a dysregulation in serotonin function has also been implicated in the pathophysiology of depression. The essential amino acid tryptophan is the precursor for both serotonin and melatonin production… CONTINUE READING

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