Effects of acute tryptophan depletion on mood and suicidal ideation in bipolar patients symptomatically stable on lithium.

@article{Hughes2000EffectsOA,
  title={Effects of acute tryptophan depletion on mood and suicidal ideation in bipolar patients symptomatically stable on lithium.},
  author={John Hughes John. Hughes and Fionnuala Dunne and Allan Hunter Young},
  journal={The British journal of psychiatry : the journal of mental science},
  year={2000},
  volume={177},
  pages={
          447-51
        }
}
BACKGROUND Previous studies suggest that brain serotonin neurotransmission may mediate the actions of lithium carbonate. Acute tryptophan depletion reduces brain serotonin and allows the study of this neurotransmitter in patient groups. AIMS To examine the effects of acute tryptophan depletion on mood and suicidal ideation in bipolar patients who were symptomatically stable on lithium. METHOD Nineteen subjects satisfying DSM-IV criteria for bipolar I disorder participated in a within… CONTINUE READING

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