Effects of acute morphine pretreatment on the rate-decreasing and antagonist activity of naloxone

@article{Young1986EffectsOA,
  title={Effects of acute morphine pretreatment on the rate-decreasing and antagonist activity of naloxone},
  author={Alice M. Young},
  journal={Psychopharmacology},
  year={1986},
  volume={88},
  pages={201-208}
}
  • Alice M. Young
  • Published in Psychopharmacology 1986
  • Psychology, Medicine
  • Rats responded under a schedule in which every 30th lever press (fixed ratio 30) produced a food pellet during sessions divided into six 5-min ratio components separated by 10-min timeout (TO) periods. Cumulative doses of morphine or naloxone were administered at the start of consecutive TO periods. When given alone, morphine decreased response rates in a dose-dependent manner, abolishing responding at 10 or 17.8 mg/kg. Naloxone doses of 0.1 and 1.0 mg/kg restored rates and patterns of behavior… CONTINUE READING

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