Effects of acute hyperoxic exposure on solute fluxes across the blood-gas barrier in rat lungs.

@article{Zheng1997EffectsOA,
  title={Effects of acute hyperoxic exposure on solute fluxes across the blood-gas barrier in rat lungs.},
  author={Lu P. Zheng and Rui Du and Barbara E. Goodman},
  journal={Journal of applied physiology},
  year={1997},
  volume={82 1},
  pages={240-7}
}
We investigated effects of acute hyperoxia on solute transport from air space to vascular space in isolated rat lungs. Air spaces were filled with Krebs-Ringer bicarbonate solution containing fluorescein isothiocyanate-labeled dextran (FD-20; mol wt 20,000) and either 22Na+ and [14C]sucrose, or D-[14C]glucose and L-[3H]glucose. Apparent permeability-surface area products for tracers over time (up to 120 min) were calculated for isolated perfused lungs from control rats (room air) and rats… CONTINUE READING

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