Effects of acute fluoxetine on extracellular serotonin levels in the raphe: an in vivo microdialysis study.

@article{Malagi1995EffectsOA,
  title={Effects of acute fluoxetine on extracellular serotonin levels in the raphe: an in vivo microdialysis study.},
  author={Isabelle Malagi{\'e} and A C Trillat and Christian Jacquot and Alain Michel Gardier},
  journal={European journal of pharmacology},
  year={1995},
  volume={286 2},
  pages={213-7}
}
Acute administration of fluoxetine (1, 10 and 20 mg/kg i.p.) increased extracellular levels of serotonin (5-hydroxytryptamine, 5-HT) in the frontal cortex, ventral hippocampus and raphe nuclei as measured by in vivo microdialysis in anaesthetized rats. In the frontal cortex, fluoxetine showed a marked dose-response effect whereas in the ventral hippocampus and raphe nuclei the fluoxetine-induced effect was maximum at 10 mg/kg. However, the maximal increase in 5-HT was observed in the cell body… CONTINUE READING