Effects of acute ethanol administration on the uptake of 59Fe-labeled transferrin by rat liver and cerebellum.

@article{Rouach1994EffectsOA,
  title={Effects of acute ethanol administration on the uptake of 59Fe-labeled transferrin by rat liver and cerebellum.},
  author={H{\'e}l{\`e}ne Rouach and Pascal Houz{\'e} and Maximilien Gentil and Marie Th{\'e}r{\`e}se Orfanelli and Roger Nordmann},
  journal={Biochemical pharmacology},
  year={1994},
  volume={47 10},
  pages={
          1835-41
        }
}
The uptake of iron by the liver and cerebellum was measured in rats using [59Fe]transferrin. An acute ethanol load (50 mmol/kg body wt., i.p.) elicited a significant increase in the hepatic and cerebellar non-heme iron concentration. The uptake of 59Fe by the liver and the cerebellum was significantly greater in the ethanol-treated rats than in control animals. The administration of allopurinol prior to the ethanol load prevented the changes in liver and cerebellar non-heme iron content… CONTINUE READING

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