Effects of acute changes of plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjects.

@article{Boden2001EffectsOA,
  title={Effects of acute changes of plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjects.},
  author={Guenther Boden and Brett D Lebed and Michael N Schatz and Carol J. Homko and Simone Lemieux},
  journal={Diabetes},
  year={2001},
  volume={50 7},
  pages={1612-7}
}
The reason for the 3- to 4-h delay between a rise in plasma free fatty acid (FFA) levels and the development of insulin resistance remains unknown. In the current study, we have tested the hypothesis that the delay may be caused by the need for plasma FFAs to first enter muscle cells and to be re-esterified there before causing insulin resistance. To this end, we have determined intramyocellular triglyceride (IMCL-TG) content with proton nuclear magnetic resonance ((1)H-NMR) spectroscopy in… CONTINUE READING
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Association of increased PLASMA FFAs AND INTRAMYOCELLULAR FAT 1616 DIABETES

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VOL. 50, • 2001
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