Effects of acute and subchronic treatments with fluoxetine and desipramine on the memory of fear in moderate and high-intensity contextual conditioning.

@article{Santos2006EffectsOA,
  title={Effects of acute and subchronic treatments with fluoxetine and desipramine on the memory of fear in moderate and high-intensity contextual conditioning.},
  author={Julia Maria dos Santos and Raquel Chacon Ruiz Martinez and Marcus Lira Brand{\~a}o},
  journal={European journal of pharmacology},
  year={2006},
  volume={542 1-3},
  pages={121-8}
}
Selective serotonin and noradrenalin reuptake inhibitors such as fluoxetine and desipramine, respectively, are efficacious in the treatment of depression and chronic stress. Although they inhibit the reuptake of the biogenic monoamines soon after administration, therapeutic improvements occur only after 2 or 3 weeks. Freezing response and potentiated startle are common responses to moderate fear contextual conditioning. However, freezing but not startle is increased in rats that undergo intense… CONTINUE READING

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