Effects of acute and subchronic administration of typical and atypical antipsychotic drugs on the neurotensin system of the rat brain.

@article{Kinkead2000EffectsOA,
  title={Effects of acute and subchronic administration of typical and atypical antipsychotic drugs on the neurotensin system of the rat brain.},
  author={Becky Kinkead and Subhan Shahid and Michael J. Owens and Charles B. Nemeroff},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2000},
  volume={295 1},
  pages={67-73}
}
The acute and subchronic effects of a variety of doses of a prototype typical (haloperidol) or one of several atypical antipsychotic drugs (clozapine, olanzapine, risperidone, quetiapine, or sertindole) on regional brain neurotensin (NT) tissue concentrations, and NT receptor binding were examined. Acute administration of haloperidol, clozapine, olanzapine, and risperidone dose-dependently increased NT tissue concentrations in the nucleus accumbens. Haloperidol, olanzapine, risperidone, and… CONTINUE READING

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